# Best Electronic Trial Master File (eTMF) Software

## How Many Electronic Trial Master File (eTMF) Software Products Does G2 Track?

**Total Products under this Category:** 39

### Category Stats (Jul 2026)

- **Average Rating:** 4.4/5 The average rating of products in this category, based on all submitted ratings

_Last updated: July 14, 2026_

## How Does G2 Rank Electronic Trial Master File (eTMF) Software Products?

**Why You Can Trust G2's Software Rankings:**

- 30 Analysts and Data Experts
- 2,300+ Authentic Reviews
- 39+ Products
- Unbiased Rankings

G2's software rankings are built on verified user reviews, rigorous moderation, and a consistent research methodology maintained by a team of analysts and data experts. Each product is measured using the same transparent criteria, with no paid placement or vendor influence. While reviews reflect real user experiences, which can be subjective, they offer valuable insight into how software performs in the hands of professionals. Together, these inputs power the G2 Score, a standardized way to compare tools within every category.

## G2 Grid® for Electronic Trial Master File (eTMF) Software
 ![G2 Grid® for Electronic Trial Master File (eTMF) Software plotting products by satisfaction and market presence](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.png?focus%5B%5D=18510&focus%5B%5D=2083&focus%5B%5D=2511&focus%5B%5D=94249&focus%5B%5D=1315744&focus%5B%5D=134478&focus%5B%5D=122044)

Highlighted products: MasterControl Quality Management System, Egnyte, Veeva Vault, Viedoc, Kivo, Clinical Research Suite, and ACE.

Underlying data: [Grid® JSON](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.json?focus%5B%5D=mastercontrol-quality-management-system&focus%5B%5D=egnyte&focus%5B%5D=veeva-vault&focus%5B%5D=viedoc&focus%5B%5D=kivo&focus%5B%5D=clinical-research-suite&focus%5B%5D=psc-software-ace)

### [Florence eTMF](https://www.g2.com/products/florence-etmf/reviews)

Florence software connects home health care data from outside the clinic with the healthcare community.

**Average Rating:** 5.0/5.0

**Total Reviews:** 1

#### Who Is the Company Behind Florence eTMF?

- **Seller:** [Florence Healthcare](https://www.g2.com/sellers/florence-healthcare)
- **Year Founded:** 2014
- **HQ Location:** Atlanta, Georgia
- **Twitter:** @FlorenceHCare (904 Twitter followers)
- **LinkedIn® Page:** https://www.linkedin.com/company/florence-healthcare/ (355 employees on LinkedIn®)

#### Who Uses This Product?

- **Company Size:** 100% Small

#### What Are Recent G2 Reviews of Florence eTMF?

**["eTMF used for a clinical trial"](https://www.g2.com/survey_responses/florence-etmf-review-5207252)**

**Rating:** 5.0/5.0 stars

_— Sivan P._

[Read full review](https://www.g2.com/survey_responses/florence-etmf-review-5207252)

### [Aurea Compliance Manager](https://www.g2.com/products/aurea-compliance-manager/reviews)

Aurea Compliance Manager delivers end-to-end integrated solutions designed to address the specific workflow and compliance needs in the Life Sciences.

#### Who Is the Company Behind Aurea Compliance Manager?

- **Seller:** [Aurea Software](https://www.g2.com/sellers/aurea-software)
- **Year Founded:** 2012
- **HQ Location:** Austin, TX
- **Twitter:** @AureaSoftware (481 Twitter followers)
- **LinkedIn® Page:** https://www.linkedin.com/company/2923561/ (233 employees on LinkedIn®)

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Similar Categories

- [Clinical Trial Management Systems](/categories/clinical-trial-management-systems)

- [Electronic Data Capture (EDC)](/categories/electronic-data-capture-edc)

[Browse Electronic Trial Master File (eTMF) Themes](/categories/electronic-trial-master-file-etmf/themes)

 ![Emma Stein](/assets/transparent-ad5be28fbcd25b7b08d2cebe1d957125437fb5407d75ee717965ad22c8808791.gif "Emma Stein")
ES

Researched and written by [Emma Stein](https://research.g2.com/insights/author/emma-stein)

Updated October 3, 2024

Electronic trial master file (eTMF) software is a specialized content management system that captures, stores, and manages all essential documents and images from a clinical trial. These solutions speed up content management via templates, mobile scanning, document classification, AI-powered automation, and approval workflows.

Organizations such as pharmaceutical and biotech companies that conduct regulated clinical trials need to maintain a TMF to comply with government regulatory requirements. By digitizing essential trial documents and content, an eTMF offers greater quality control and visibility over processes and documentation, making it easier to audit content throughout the trial lifecycle to ensure compliance is being met. Sites, sponsors, and contract research organizations (CROs) can collaborate in real-time on the TMF, track key metrics for study completion, share and migrate content, and search and filter data.

An eTMF supports [clinical trial management software](https://www.g2.com/categories/clinical-trial-management) and [electronic data capture (EDC) software](https://www.g2.com/categories/electronic-data-capture-edc) by importing documents from both solutions, as well as automating the creation and filing of new documents using information stored in both.

To qualify for inclusion in the Electronic Trial Master File (eTMF) category, a product must:

- Provide pre-built and customizable TMF reference models, and allow specifications to be configured at the study, country, and site levels
- Track the status of all necessary trial documents from missing to completed stages and provide analytics
- Establish review and approval workflows
- Allow document authoring and collaboration between internal and external parties
- Comply with all relevant government regulatory requirements for clinical trials, such as 21 CFR Part 11, HIPAA, ANNEX 11, GxP, and GDPR

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