# Best Electronic Trial Master File (eTMF) Software for Medium-Sized Businesses ## How Many Electronic Trial Master File (eTMF) Software Products Does G2 Track? **Total Products under this Category:** 39 ### Category Stats (Aug 2026) - **Average Rating:** 4.4/5 The average rating of products in this category, based on all submitted ratings _Last updated: August 14, 2026_ ## How Does G2 Rank Electronic Trial Master File (eTMF) Software Products? **Why You Can Trust G2's Software Rankings:** - 30 Analysts and Data Experts - 2,300+ Authentic Reviews - 39+ Products - Unbiased Rankings G2's software rankings are built on verified user reviews, rigorous moderation, and a consistent research methodology maintained by a team of analysts and data experts. Each product is measured using the same transparent criteria, with no paid placement or vendor influence. While reviews reflect real user experiences, which can be subjective, they offer valuable insight into how software performs in the hands of professionals. Together, these inputs power the G2 Score, a standardized way to compare tools within every category. ## G2 Grid® for Electronic Trial Master File (eTMF) Software ![G2 Grid® for Electronic Trial Master File (eTMF) Software plotting products by satisfaction and market presence](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.png?focus%5B%5D=18510&focus%5B%5D=2511&focus%5B%5D=2083) Highlighted products: MasterControl Quality Management System, Veeva Vault, and Egnyte. Underlying data: [Grid® JSON](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.json?focus%5B%5D=mastercontrol-quality-management-system&focus%5B%5D=veeva-vault&focus%5B%5D=egnyte&segment=mid-market) **Sponsored** ### Cedreo Cedreo is the only cloud-based 3D architecture software designed specifically for building and remodeling professionals — with zero learning curve required. Create professional conceptual designs in just 2 hours, even with no design experience. From concept to presentation: - Professional 2D and 3D floor plans - Detailed electrical and site plans - Cross-sections and elevation drawings - Photorealistic 3D renderings of interiors and exteriors - Automated surface area reports - Client-ready proposal documents with your branding Why building and remodeling professionals love Cedreo: ✓ Learn in minutes, not months - Intuitive drag-and-drop interface anyone can master ✓ Keep design in-house - No more waiting weeks for external designers nor costly design fees ✓ Close deals on the spot - Show breathtaking 3D renderings during your first meeting Perfect for professionals who want to win more jobs without the complexity of traditional design software. [Visit website](https://www.g2.com/external_clickthroughs/record?secure%5Bad_program%5D=ppc&secure%5Bad_slot%5D=category_product_list_llm&secure%5Bcategory_id%5D=1005193&secure%5Bchosen_at%5D=2026-08-15T14%3A52%3A16Z&secure%5Bdisplayable_resource_id%5D=2228&secure%5Bdisplayable_resource_type%5D=Category&secure%5Bmedium%5D=sponsored&secure%5Bplacement_reason%5D=retargeted_product&secure%5Bplacement_resource_ids%5D%5B%5D=69227&secure%5Bprioritized%5D=false&secure%5Bproduct_id%5D=69227&secure%5Bresource_id%5D=1005193&secure%5Bresource_type%5D=Category&secure%5Bsource_type%5D=category_page&secure%5Bsource_url%5D=https%3A%2F%2Fwww.g2.com%2Fcategories%2Felectronic-trial-master-file-etmf%2Fmid-market&secure%5Btoken%5D=67dc2c2da0def6924b2140d8fdc5b429c038bb2bb92a0c08955b390c69ea2ac8&secure%5Burl%5D=https%3A%2F%2Fcedreo.com%2Fsignup%2F%3Futm_campaign%3D25017129-g2-sponsored%26utm_source%3Dg2%26utm_medium%3Ddirectories%26utm_content%3Dsponsored&secure%5Burl_type%5D=free_trial) ### [MasterControl Quality Management System](https://www.g2.com/products/mastercontrol-quality-management-system/reviews) MasterControl Quality Excellence is the #1 Quality Management System (QMS) in life sciences. Built on an AI-driven platform, it enables life-sciences companies to enable flexible quality event management, simplified document management, and automated training management—that all work seamlessly together to close the loop on quality. Targeted primarily at quality professionals within the life sciences industry, MasterControl Qx serves a diverse range of organizations, from pharmaceuticals to biotechnology and medical devices. These industries often face stringent regulatory requirements and complex quality assurance processes. MasterControl Qx offers a centralized platform that integrates various quality management functions, allowing users to manage quality events, documentation, training, and audits seamlessly. This integration not only enhances operational efficiency but also ensures that organizations remain compliant with industry standards. One of the standout features of MasterControl Qx is its intelligent automation capabilities. By automating routine quality management tasks, organizations can reduce manual errors and free up valuable time for quality professionals to focus on more strategic initiatives. Additionally, the platform provides robust data insights that empower users to make informed decisions based on real-time information. This data-driven approach enhances the ability to identify trends, monitor compliance, and drive continuous improvement within quality processes. Furthermore, MasterControl Qx is designed to foster collaboration across departments and teams. The platform's connected nature allows for easy sharing of information and documentation, ensuring that all stakeholders are aligned and informed. This collaborative environment not only enhances communication but also supports a culture of quality throughout the organization. By utilizing MasterControl Qx, companies can create a more agile and responsive quality management system that adapts to changing regulatory landscapes and market demands. Overall, MasterControl Quality Excellence (Qx) stands out in the QMS category by providing a holistic solution tailored to the specific needs of the life sciences industry. Its combination of intelligent automation, robust data insights, and collaborative features positions it as a valuable tool for organizations striving to maintain high-quality standards while navigating the complexities of regulatory compliance. **Average Rating:** 4.3/5.0 **Total Reviews:** 526 #### How Do G2 Users Rate MasterControl Quality Management System? - **Ease of Use:** 7.8/10 (Category avg: 8.9/10) - **Quality of Support:** 8.6/10 (Category avg: 8.3/10) #### Who Is the Company Behind MasterControl Quality Management System? - **Seller:** [MasterControl](https://www.g2.com/sellers/mastercontrol) - **Company Website:** www.mastercontrol.com - **Year Founded:** 1993 - **HQ Location:** Salt Lake City, UT - **Twitter:** @MCMasterControl 6,258 Twitter followers - **LinkedIn® Page:** [www.linkedin.com](https://www.g2.com/external_clickthroughs/record?secure%5Bsource_type%5D=product_profile&secure%5Btoken%5D=00588802c89147f00f07e6bed17054a50d4b885bbdcab7c82c6ef17d1397df09&secure%5Burl%5D=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2F23070%2F&secure%5Burl_type%5D=linkedin_company_website) 742 employees on LinkedIn® #### Who Uses This Product? - **Who Uses This:** Quality Assurance Specialist, Quality Engineer - **Top Industries:** Pharmaceuticals, Medical Devices - **Company Size:** 64% Medium, 25% Large #### What Do G2 Reviewers Say About MasterControl Quality Management System? _AI-generated summary from verified user reviews_ ##### Pros - Users appreciate the **ease of use** of MasterControl, benefiting from its intuitive interface and customizable features. - Users value the **centralized document management** features of MasterControl, enhancing integration and user experience effectively. - Users value the **user-friendly training integration** and centralized system for managing compliance and quality events effectively. - Users value the **efficient document control** in MasterControl, appreciating easy access to documents and timely upgrades. - Users appreciate the **customizable and user-friendly features** of MasterControl, facilitating efficient quality management processes. ##### Cons - Users find the **interface not intuitive** , struggling with complex setups and unclear iconography affecting user experience. - Users face a **steep learning curve** with MasterControl, particularly during initial setup and navigation between modules. - Users find the **difficult usability** of MasterControl's system a challenge, particularly with report creation and workflow setup. - Users struggle with the **not user-friendly interface** of MasterControl, finding navigation and search features cumbersome and challenging. - Users find the **complex setup** challenging, requiring extensive training to effectively use MasterControl's capabilities. #### What Are Recent G2 Reviews of MasterControl Quality Management System? **["Perfect for life sciences companies!"](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-12477103)** **Rating:** 4.0/5.0 stars _— Sean M._ [Read full review](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-12477103) **["Document Management not Just for Life Sciences"](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-7875253)** **Rating:** 4.0/5.0 stars _— Travis B._ [Read full review](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-7875253) #### What Are G2 Users Discussing About MasterControl Quality Management System? - [What is MasterControl Quality Management System used for?](https://www.g2.com/discussions/what-is-mastercontrol-quality-management-system-used-for) - 1 comment - [What is MasterControl Customer Complaints used for?](https://www.g2.com/discussions/what-is-mastercontrol-customer-complaints-used-for) ### [Veeva Vault](https://www.g2.com/products/veeva-vault/reviews) Veeva Vault is a cloud-based platform specifically designed for the life sciences industry, integrating content and data management to streamline complex processes across research and development (R&D), regulatory affairs, quality management, and commercial operations. By unifying documents and structured data within a single system, Vault enhances collaboration, ensures compliance, and accelerates product development cycles. Key Features and Functionality: - Unified Content and Data Management: Vault manages both documents and structured data, providing a single source of truth that eliminates information silos and enhances data integrity. - Agentic AI Integration: The platform incorporates built-in agentic AI, enabling the creation and configuration of AI agents that operate within Veeva applications, facilitating intelligent automation and decision-making. - Configurable Workflows: Users can automate business processes with customizable workflows, including task assignments, notifications, and escalations, to improve operational efficiency. - Compliance and Validation: Vault is designed to meet rigorous compliance standards, offering features like audit trails, electronic signatures, and validation processes to ensure adherence to industry regulations. - Scalable Cloud Architecture: The platform's cloud-native design supports global scalability, allowing organizations to adapt to evolving business needs and performance requirements. Primary Value and Solutions Provided: Veeva Vault addresses the challenges of managing complex, regulated processes in the life sciences sector by offering a unified platform that integrates content and data management. This integration enhances collaboration among internal teams and external partners, ensures compliance with industry regulations, and accelerates product development and commercialization. By providing a scalable, configurable, and secure environment, Vault enables organizations to improve operational efficiency, reduce time-to-market, and maintain high standards of quality and compliance. **Average Rating:** 4.1/5.0 **Total Reviews:** 52 #### How Do G2 Users Rate Veeva Vault? - **Ease of Use:** 7.7/10 (Category avg: 8.9/10) - **Quality of Support:** 8.6/10 (Category avg: 8.3/10) #### Who Is the Company Behind Veeva Vault? - **Seller:** [Veeva](https://www.g2.com/sellers/veeva) - **Year Founded:** 2007 - **HQ Location:** Pleasanton, CA - **Twitter:** @veevasystems 6,133 Twitter followers - **LinkedIn® Page:** [www.linkedin.com](https://www.g2.com/external_clickthroughs/record?secure%5Bsource_type%5D=product_profile&secure%5Btoken%5D=09d1882ac479495db33963e82af224cfab6bd595516d089eb06329a0022b3561&secure%5Burl%5D=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2F402048%2F&secure%5Burl_type%5D=linkedin_company_website) 9,958 employees on LinkedIn® - **Ownership:** NYSE: VEEV #### Who Uses This Product? - **Top Industries:** Pharmaceuticals, Biotechnology - **Company Size:** 46% Large, 28% Medium #### What Are Recent G2 Reviews of Veeva Vault? **["Veeva Vault Feels Like the Gold Standard for Regulatory Robustness"](https://www.g2.com/survey_responses/veeva-vault-review-12652062)** **Rating:** 5.0/5.0 stars _— Ender Efe C._ [Read full review](https://www.g2.com/survey_responses/veeva-vault-review-12652062) **["Unified CTMS & eTMF That Enables Strategic Trial Oversight and Always-On Inspection Readiness"](https://www.g2.com/survey_responses/veeva-vault-review-12691241)** **Rating:** 5.0/5.0 stars _— Dimple R._ [Read full review](https://www.g2.com/survey_responses/veeva-vault-review-12691241) #### What Are G2 Users Discussing About Veeva Vault? - [What is Veeva Vault used for?](https://www.g2.com/discussions/veeva-vault-what-is-veeva-vault-used-for) - [Is Veeva Vault built on Salesforce?](https://www.g2.com/discussions/veeva-vault-is-veeva-vault-built-on-salesforce) - [How does Veeva Vault work?](https://www.g2.com/discussions/how-does-veeva-vault-work) - [What is Veeva Vault built on?](https://www.g2.com/discussions/what-is-veeva-vault-built-on) - [What is Veeva Vault used for?](https://www.g2.com/discussions/what-is-veeva-vault-used-for) ### [Egnyte](https://www.g2.com/products/egnyte/reviews) Egnyte combines the power of cloud content management, data security, and AI into one intelligent content platform. More than 22,000 customers trust Egnyte to improve employee productivity, automate business processes, and safeguard critical data, in addition to offering specialized content intelligence and automation solutions across industries, including architecture, engineering, and construction (AEC), life sciences, and financial services. **Average Rating:** 4.4/5.0 **Total Reviews:** 1,137 #### How Do G2 Users Rate Egnyte? - **Ease of Use:** 9.0/10 (Category avg: 8.9/10) - **Quality of Support:** 8.8/10 (Category avg: 8.3/10) #### Who Is the Company Behind Egnyte? - **Seller:** [Egnyte](https://www.g2.com/sellers/egnyte) - **Company Website:** www.egnyte.com - **Year Founded:** 2008 - **HQ Location:** Mountain View, CA - **Twitter:** @Egnyte 16,127 Twitter followers - **LinkedIn® Page:** [www.linkedin.com](https://www.g2.com/external_clickthroughs/record?secure%5Bsource_type%5D=product_profile&secure%5Btoken%5D=31d0612f324184ba5e281bcff6bf94116753a22d2f35e998950a1c5df7a2c1d6&secure%5Burl%5D=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2F1015589%2F&secure%5Burl_type%5D=linkedin_company_website) 1,305 employees on LinkedIn® #### Who Uses This Product? - **Who Uses This:** Project Manager, Owner - **Top Industries:** Construction, Marketing and Advertising - **Company Size:** 44% Small, 38% Medium #### What Do G2 Reviewers Say About Egnyte? _AI-generated summary from verified user reviews_ ##### Pros - Users appreciate the **ease of use** of Egnyte, highlighting its user-friendly interface and seamless integration with tools. - Users value the **ease of file sharing** with Egnyte, enabling smooth collaboration and secure access across teams. - Users value the **easy sharing** feature of Egnyte, enhancing collaboration for remote and in-office team members alike. - Users value the **robust security features** of Egnyte, ensuring their data is well protected and compliant. - Users appreciate the **easy access** to documents, enabling seamless sharing and collaboration with peers and subcontractors. ##### Cons - Users find Egnyte to be **expensive** , especially for small businesses, coupled with inflexible billing practices. - Users note the **slow drive accessibility** at startup and challenges with file locks and O365 sharing in Egnyte. - Users find Egnyte's **limited features** frustrating, particularly in bulk actions and user permission customizations. - Users find Egnyte's interface **clunky and slow** , making navigation and file management more challenging than expected. - Users find **lacking features** in Egnyte, struggling with bulk actions and unclear AI training tools. #### What Are Recent G2 Reviews of Egnyte? **["Secure, Powerful AI Collaboration with Outstanding Workflow Management"](https://www.g2.com/survey_responses/egnyte-review-12819916)** **Rating:** 4.5/5.0 stars _— Konjengbam M._ [Read full review](https://www.g2.com/survey_responses/egnyte-review-12819916) **["Easy way to manage, Share and secure files With team collaboration"](https://www.g2.com/survey_responses/egnyte-review-12753699)** **Rating:** 5.0/5.0 stars _— Ishan S._ [Read full review](https://www.g2.com/survey_responses/egnyte-review-12753699) #### What Are G2 Users Discussing About Egnyte? - [What is Egnyte used for?](https://www.g2.com/discussions/egnyte-what-is-egnyte-used-for) - 1 comment - [Is egnyte secure?](https://www.g2.com/discussions/is-egnyte-secure) - 1 comment - [What is egnyte used for?](https://www.g2.com/discussions/what-is-egnyte-used-for) - 2 comments - [What is egnyte software?](https://www.g2.com/discussions/what-is-egnyte-software) - 1 comment Spotlight Categories [Lead Intelligence Software](https://www.g2.com/categories/lead-intelligence) [Employee Recognition Software](https://www.g2.com/categories/employee-recognition) [Influencer Marketing Platforms](https://www.g2.com/categories/influencer-marketing-platforms) [Sales Performance Management Software](https://www.g2.com/categories/sales-performance-management) [Travel Management Solutions](https://www.g2.com/categories/travel-management) Similar Categories - [Clinical Trial Management Systems](/categories/clinical-trial-management-systems) - [Electronic Data Capture (EDC)](/categories/electronic-data-capture-edc) [Browse Electronic Trial Master File (eTMF) Themes](/categories/electronic-trial-master-file-etmf/themes)