# Best Electronic Trial Master File (eTMF) Software for Small Business *By [Emma Stein](https://research.g2.com/insights/author/emma-stein)* Products classified in the overall Electronic Trial Master File (eTMF) category are similar in many regards and help companies of all sizes solve their business problems. However, small business features, pricing, setup, and installation differ from businesses of other sizes, which is why we match buyers to the right Small Business Electronic Trial Master File (eTMF) to fit their needs. Compare product ratings based on reviews from enterprise users or connect with one of G2's buying advisors to find the right solutions within the Small Business Electronic Trial Master File (eTMF) category. In addition to qualifying for inclusion in the Electronic Trial Master File (eTMF) Software category, to qualify for inclusion in the Small Business Electronic Trial Master File (eTMF) Software category, a product must have at least 10 reviews left by a reviewer from a small business. ## G2 Grid® for Electronic Trial Master File (eTMF) Software ![G2 Grid® for Electronic Trial Master File (eTMF) Software plotting products by satisfaction and market presence](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.png?focus%5B%5D=2083&focus%5B%5D=94249&focus%5B%5D=134478&focus%5B%5D=18510) Highlighted products: Egnyte, Viedoc, Clinical Research Suite, and MasterControl Quality Management System. Underlying data: [Grid® JSON](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.json?focus%5B%5D=egnyte&focus%5B%5D=viedoc&focus%5B%5D=clinical-research-suite&focus%5B%5D=mastercontrol-quality-management-system&segment=small-business) ## How Many Electronic Trial Master File (eTMF) Software Products Does G2 Track? **Total Products under this Category:** 38 ### Category Stats (Jul 2026) - **Average Rating**: 4.4/5 The average rating of products in this category, based on all submitted ratings *Last updated: July 14, 2026* ## How Does G2 Rank Electronic Trial Master File (eTMF) Software Products? **Why You Can Trust G2's Software Rankings:** - 30 Analysts and Data Experts - 2,300+ Authentic Reviews - 38+ Products - Unbiased Rankings G2's software rankings are built on verified user reviews, rigorous moderation, and a consistent research methodology maintained by a team of analysts and data experts. Each product is measured using the same transparent criteria, with no paid placement or vendor influence. While reviews reflect real user experiences, which can be subjective, they offer valuable insight into how software performs in the hands of professionals. Together, these inputs power the G2 Score, a standardized way to compare tools within every category. ## What Are the Top-Rated Electronic Trial Master File (eTMF) Software Products in 2026? ### 1. [Egnyte](https://www.g2.com/products/egnyte/reviews) Egnyte combines the power of cloud content management, data security, and AI into one intelligent content platform. More than 22,000 customers trust Egnyte to improve employee productivity, automate business processes, and safeguard critical data, in addition to offering specialized content intelligence and automation solutions across industries, including architecture, engineering, and construction (AEC), life sciences, and financial services. **Average Rating:** 4.4/5.0 **Total Reviews:** 1,136 **How Do G2 Users Rate Egnyte?** - **Ease of Use:** 9.0/10 (Category avg: 8.9/10) - **Quality of Support:** 8.8/10 (Category avg: 8.3/10) **Who Is the Company Behind Egnyte?** - **Seller:** [Egnyte](https://www.g2.com/sellers/egnyte) - **Company Website:** https://www.egnyte.com - **Year Founded:** 2008 - **HQ Location:** Mountain View, CA - **Twitter:** @Egnyte (16,127 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/1015589/ (1,302 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** Project Manager, Owner - **Top Industries:** Construction, Marketing and Advertising - **Company Size:** 44% Small-Business, 38% Mid-Market #### What Are Egnyte's Pros and Cons? **Pros:** - Ease of Use (119 reviews) - File Sharing (69 reviews) - Easy Sharing (53 reviews) - Easy Access (45 reviews) - Security (44 reviews) **Cons:** - Expensive (21 reviews) - File Management (19 reviews) - User Difficulty (13 reviews) - Lacking Features (12 reviews) - Missing Features (12 reviews) ### What Do G2 Reviewers Say About Egnyte? *AI-generated summary from verified user reviews* **Pros:** - Users appreciate the **ease of use** of Egnyte, enjoying its user-friendly interface and seamless integration. - Users appreciate the **seamless file sharing** capabilities of Egnyte, enhancing collaboration and workflow efficiency across teams. - Users value the **easy sharing features** of Egnyte, enhancing collaboration across departments with confidence and efficiency. - Users appreciate the **easy access** to files from anywhere, ensuring productivity and reliability on the go. - Users value the **high security** of Egnyte, finding it trustworthy for their sensitive data storage needs. **Cons:** - Users find Egnyte to be **expensive** , especially for small businesses needing larger storage plans. - Users experience **file management failures and timeouts** , leading to frustrations with saving and duplication issues. - Users find that **using Egnyte on mobile is more difficult** than on a computer, affecting overall usability. - Users find Egnyte **lacking essential features** such as clear visibility of user actions and effective file handling capabilities. - Users find the **missing features** restrict collaborative and 3D capabilities, hindering their project workflows. #### What Are Recent G2 Reviews of Egnyte? **"[Secure, Powerful AI Collaboration with Outstanding Workflow Management](https://www.g2.com/survey_responses/egnyte-review-12819916)"** **Rating:** 4.5/5.0 stars *— Konjengbam M.* [Read full review](https://www.g2.com/survey_responses/egnyte-review-12819916) --- **"[Secure, Seamless File Sharing with Strong Collaboration and Governance](https://www.g2.com/survey_responses/egnyte-review-13088921)"** **Rating:** 4.5/5.0 stars *— Dharamveer p.* [Read full review](https://www.g2.com/survey_responses/egnyte-review-13088921) --- #### What Are G2 Users Discussing About Egnyte? - [What is Egnyte used for?](https://www.g2.com/discussions/egnyte-what-is-egnyte-used-for) - 1 comment - [Is egnyte secure?](https://www.g2.com/discussions/is-egnyte-secure) - 1 comment - [What is egnyte used for?](https://www.g2.com/discussions/what-is-egnyte-used-for) - 2 comments - [What is egnyte software?](https://www.g2.com/discussions/what-is-egnyte-software) - 1 comment ### 2. [Viedoc](https://www.g2.com/products/viedoc/reviews) Viedoc streamlines clinical trials with a powerful, web-based eClinical suite centered around EDC. Designed for efficiency, compliance, and seamless collaboration, our feature-rich platform accelerates research and simplifies data collection, management, and analysis. Trusted in 75+ countries, Viedoc powers 7,000+ studies with more than 1.6M+ participants, bringing life-changing treatments to market faster. **Average Rating:** 4.5/5.0 **Total Reviews:** 225 **How Do G2 Users Rate Viedoc?** - **Ease of Use:** 9.2/10 (Category avg: 8.9/10) - **Quality of Support:** 9.2/10 (Category avg: 8.3/10) **Who Is the Company Behind Viedoc?** - **Seller:** [Viedoc Technologies](https://www.g2.com/sellers/viedoc-technologies) - **Company Website:** https://www.viedoc.com/ - **Year Founded:** 2003 - **HQ Location:** Uppsala, Uppsala County - **Twitter:** @ViedocOfficial (200 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/viedoctechnologies/ (129 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** Data Manager, Associate Analyst - **Top Industries:** Pharmaceuticals, Research - **Company Size:** 37% Enterprise, 33% Mid-Market #### What Are Viedoc's Pros and Cons? **Pros:** - Ease of Use (37 reviews) - User Interface (30 reviews) - Intuitive (23 reviews) - Customer Support (21 reviews) - Features (21 reviews) **Cons:** - Slow Performance (13 reviews) - Difficulty (11 reviews) - Access Control (8 reviews) - Form Design Issues (8 reviews) - Missing Features (7 reviews) ### What Do G2 Reviewers Say About Viedoc? *AI-generated summary from verified user reviews* **Pros:** - Users praise the **ease of use** of Viedoc, highlighting its intuitive design and effortless navigation. - Users value the **easy-to-use interface** of Viedoc, enhancing navigation and simplifying data entry tasks. - Users praise Viedoc for its **intuitive interface** , which simplifies navigation and enhances efficiency in clinical data management. - Users praise the **responsive customer support** of Viedoc, highlighting quick assistance and expert guidance at every stage. - Users appreciate the **ease of use and robust features** of Viedoc, enhancing efficiency and workflow in data management. **Cons:** - Users experience **slow performance** with Viedoc, especially when handling larger studies or specific modules like RTSM. - Users find Viedoc's **complexity and slow performance** especially challenging when handling large datasets and intricate forms. - Users find the **role-based access control limiting** , particularly in collaborative workflows, affecting their overall experience. - Users find the **form design restrictive** , hindering more complex logic and limiting editing options in Viedoc. - Users find the **lack of repeating fields** in Viedoc complicates form creation and increases design complexity. #### What Are Recent G2 Reviews of Viedoc? **"[Simple, Versatile Design and a Product That Keeps Up With a Fast-Moving Market](https://www.g2.com/survey_responses/viedoc-review-12611501)"** **Rating:** 4.5/5.0 stars *— Marina A.* [Read full review](https://www.g2.com/survey_responses/viedoc-review-12611501) --- **"[Driving Efficiency and Data Quality in Clinical Trial Management](https://www.g2.com/survey_responses/viedoc-review-8698783)"** **Rating:** 5.0/5.0 stars *— DEEKSHITHA V.* [Read full review](https://www.g2.com/survey_responses/viedoc-review-8698783) --- #### What Are G2 Users Discussing About Viedoc? - [What is Viedoc used for?](https://www.g2.com/discussions/what-is-viedoc-used-for) - 1 comment ### 3. [Clinical Research Suite](https://www.g2.com/products/clinical-research-suite/reviews) ABOUT ResearchManager is an all-in-one platform that makes clinical research smarter, faster, and more efficient. With the Clinical Research Suite, we provide a fully integrated solution for academic institutions, healthcare organizations, CROs, and sponsors across the entire clinical research lifecycle. From study setup and regulatory approval to recruitment, data capture, and monitoring. By centralizing processes and data on a single platform, ResearchManager reduces complexity, minimizes errors, and enhances compliance and collaboration. OUR MISSION Our mission is to digitalize, accelerate, and optimize research worldwide, enabling innovative treatments and scientific insights to reach patients sooner. We believe advancing healthcare starts with advancing research, and we empower organizations to make that happen. OUR PLATFORM - THE CLINICAL RESEARCH SUITE Clinical Data Management: Tools to recruit the right participants and efficiently capture, manage, and validate research data, reducing errors and saving time. • Electronic Data Capture (EDC) • Electronic Patient-Reported Outcomes (ePRO) • Randomization and Trial Supply Management (RTSM) • Electronic Informed Consent (eConsent) • Patient Recruitment Clinical Operations: Tools that centralize submissions, documentation, and workflows to streamline trial management and strengthen collaboration. These are all modular and fully configurable. • Clinical Trial Management System (CTMS) • Electronic Trial Master File (eTMF) • Regulatory Information Management System (RIMS) LEARN MORE • Request a FREE Demo:https://my researchmanager.com/en/request-inquiry/ • Get a Price Estimate in 1 Minute: https://my-researchmanager.com/en/pricing/ **Average Rating:** 3.8/5.0 **Total Reviews:** 204 **How Do G2 Users Rate Clinical Research Suite?** - **Ease of Use:** 7.5/10 (Category avg: 8.9/10) - **Quality of Support:** 7.6/10 (Category avg: 8.3/10) **Who Is the Company Behind Clinical Research Suite?** - **Seller:** [ResearchManager](https://www.g2.com/sellers/researchmanager) - **Year Founded:** 2013 - **HQ Location:** Deventer, Overijssel - **Twitter:** @RESEARCH_MGR (96 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/research-manager/ (20 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** PhD student, Researcher - **Top Industries:** Hospital & Health Care, Research - **Company Size:** 55% Enterprise, 33% Small-Business #### What Are Clinical Research Suite's Pros and Cons? **Pros:** - Ease of Use (79 reviews) - Interface Clarity (18 reviews) - User Interface (18 reviews) - Features (17 reviews) - Data Management (14 reviews) **Cons:** - Poor Navigation (24 reviews) - Missing Features (15 reviews) - Difficulty (14 reviews) - Slow Performance (10 reviews) - Data Management Issues (8 reviews) ### What Do G2 Reviewers Say About Clinical Research Suite? *AI-generated summary from verified user reviews* **Pros:** - Users appreciate the **user-friendly interface** of Clinical Research Suite, making study management simple and intuitive. - Users appreciate the **interface clarity** of Clinical Research Suite, highlighting its ease of use and clear document overview. - Users value the **user-friendly interface** of Clinical Research Suite, enhancing usability and streamlining various operations effectively. - Users appreciate the **intuitive design and comprehensive features** of Clinical Research Suite for streamlined research and organization. - Users value the **easy-to-use data management** features of the Clinical Research Suite for effective research oversight. **Cons:** - Users find the **poor navigation** challenging, requiring time to understand and locate features in the Clinical Research Suite. - Users highlight the **missing features** in Clinical Research Suite, causing inefficiencies and confusion in their processes. - Users find a **significant learning curve** with the Clinical Research Suite, complicating navigation and functionality. - Users experience **slow performance** with the Clinical Research Suite, leading to delays while loading and editing data. - Users face **data management issues** with unclear integration and an overly complex interface that hinders efficiency. #### What Are Recent G2 Reviews of Clinical Research Suite? **"[Very friendly user interface](https://www.g2.com/survey_responses/clinical-research-suite-review-11695059)"** **Rating:** 4.5/5.0 stars *— Verified User in Medical Practice* [Read full review](https://www.g2.com/survey_responses/clinical-research-suite-review-11695059) --- **"[Very flexible software](https://www.g2.com/survey_responses/clinical-research-suite-review-10816362)"** **Rating:** 5.0/5.0 stars *— Quinty v.* [Read full review](https://www.g2.com/survey_responses/clinical-research-suite-review-10816362) --- ### 4. [MasterControl Quality Management System](https://www.g2.com/products/mastercontrol-quality-management-system/reviews) MasterControl Quality Excellence is the #1 Quality Management System (QMS) in life sciences. Built on an AI-driven platform, it enables life-sciences companies to enable flexible quality event management, simplified document management, and automated training management—that all work seamlessly together to close the loop on quality. Targeted primarily at quality professionals within the life sciences industry, MasterControl Qx serves a diverse range of organizations, from pharmaceuticals to biotechnology and medical devices. These industries often face stringent regulatory requirements and complex quality assurance processes. MasterControl Qx offers a centralized platform that integrates various quality management functions, allowing users to manage quality events, documentation, training, and audits seamlessly. This integration not only enhances operational efficiency but also ensures that organizations remain compliant with industry standards. One of the standout features of MasterControl Qx is its intelligent automation capabilities. By automating routine quality management tasks, organizations can reduce manual errors and free up valuable time for quality professionals to focus on more strategic initiatives. Additionally, the platform provides robust data insights that empower users to make informed decisions based on real-time information. This data-driven approach enhances the ability to identify trends, monitor compliance, and drive continuous improvement within quality processes. Furthermore, MasterControl Qx is designed to foster collaboration across departments and teams. The platform's connected nature allows for easy sharing of information and documentation, ensuring that all stakeholders are aligned and informed. This collaborative environment not only enhances communication but also supports a culture of quality throughout the organization. By utilizing MasterControl Qx, companies can create a more agile and responsive quality management system that adapts to changing regulatory landscapes and market demands. Overall, MasterControl Quality Excellence (Qx) stands out in the QMS category by providing a holistic solution tailored to the specific needs of the life sciences industry. Its combination of intelligent automation, robust data insights, and collaborative features positions it as a valuable tool for organizations striving to maintain high-quality standards while navigating the complexities of regulatory compliance. **Average Rating:** 4.3/5.0 **Total Reviews:** 522 **How Do G2 Users Rate MasterControl Quality Management System?** - **Ease of Use:** 7.8/10 (Category avg: 8.9/10) - **Quality of Support:** 8.6/10 (Category avg: 8.3/10) **Who Is the Company Behind MasterControl Quality Management System?** - **Seller:** [MasterControl](https://www.g2.com/sellers/mastercontrol) - **Company Website:** https://www.mastercontrol.com?utm_source=linkedin&utm_medium=about&utm_campaign=l1nk3din-sm - **Year Founded:** 1993 - **HQ Location:** Salt Lake City, UT - **Twitter:** @MCMasterControl (6,258 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/23070/ (742 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** Quality Assurance Specialist, Quality Engineer - **Top Industries:** Pharmaceuticals, Medical Devices - **Company Size:** 65% Mid-Market, 25% Enterprise #### What Are MasterControl Quality Management System's Pros and Cons? **Pros:** - Ease of Use (115 reviews) - Document Management (87 reviews) - Training (65 reviews) - Document Control (47 reviews) - Features (44 reviews) **Cons:** - Not Intuitive (43 reviews) - Learning Curve (42 reviews) - Difficult Usability (32 reviews) - Not User-Friendly (29 reviews) - Complex Setup (27 reviews) ### What Do G2 Reviewers Say About MasterControl Quality Management System? *AI-generated summary from verified user reviews* **Pros:** - Users find MasterControl QMS to be **user-friendly and intuitive** , simplifying workflows and enhancing overall usability. - Users value the **centralized document management** capabilities of MasterControl, enhancing efficiency and compliance across various functions. - Users appreciate the **centralized training system** of MasterControl, enhancing efficiency and compliance through integrated functionalities. - Users value the **effective document control** of MasterControl, enjoying easy access to documents and streamlined processes. - Users value the **customizable and easy-to-navigate features** of MasterControl, enhancing productivity in quality management processes. **Cons:** - Users find the **interface not intuitive** , making it difficult to navigate and locate essential information quickly. - Users face a **steep learning curve** with MasterControl, complicating initial setup and navigation despite its overall effectiveness. - Users find **difficult usability** in MasterControl's report creation and workflow setup, hindering their overall experience. - Users often find the **end-user interface challenging to navigate** , which complicates their overall experience with the system. - Users find the **complex setup** of MasterControl Quality Management System challenging, requiring extensive training and understanding of workflows. #### What Are Recent G2 Reviews of MasterControl Quality Management System? **"[Integrated, Compliant QMS That Streamlines Regulated Workflows](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-12851642)"** **Rating:** 5.0/5.0 stars *— Yoohan L.* [Read full review](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-12851642) --- **"[A wonderful tool for Life Sciences in an organization!](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-8510804)"** **Rating:** 5.0/5.0 stars *— Liz K.* [Read full review](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-8510804) --- #### What Are G2 Users Discussing About MasterControl Quality Management System? - [What is MasterControl Quality Management System used for?](https://www.g2.com/discussions/what-is-mastercontrol-quality-management-system-used-for) - 1 comment - [What is MasterControl Customer Complaints used for?](https://www.g2.com/discussions/what-is-mastercontrol-customer-complaints-used-for) ## What Is Electronic Trial Master File (eTMF) Software? [Clinical Research Software](https://www.g2.com/categories/clinical-research)