# Best Electronic Trial Master File (eTMF) Software for Small Business *By [Emma Stein](https://research.g2.com/insights/author/emma-stein)* Products classified in the overall Electronic Trial Master File (eTMF) category are similar in many regards and help companies of all sizes solve their business problems. However, small business features, pricing, setup, and installation differ from businesses of other sizes, which is why we match buyers to the right Small Business Electronic Trial Master File (eTMF) to fit their needs. Compare product ratings based on reviews from enterprise users or connect with one of G2's buying advisors to find the right solutions within the Small Business Electronic Trial Master File (eTMF) category. In addition to qualifying for inclusion in the Electronic Trial Master File (eTMF) Software category, to qualify for inclusion in the Small Business Electronic Trial Master File (eTMF) Software category, a product must have at least 10 reviews left by a reviewer from a small business. ## G2 Grid® for Electronic Trial Master File (eTMF) Software ![G2 Grid® for Electronic Trial Master File (eTMF) Software plotting products by satisfaction and market presence](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.png?focus%5B%5D=2083&focus%5B%5D=94249&focus%5B%5D=134478&focus%5B%5D=18510) Highlighted products: Egnyte, Viedoc, Clinical Research Suite, and MasterControl Quality Management System. Underlying data: [Grid® JSON](https://www.g2.com/categories/electronic-trial-master-file-etmf/grids.json?focus%5B%5D=egnyte&focus%5B%5D=viedoc&focus%5B%5D=clinical-research-suite&focus%5B%5D=mastercontrol-quality-management-system&segment=small-business) ## How Many Electronic Trial Master File (eTMF) Software Products Does G2 Track? **Total Products under this Category:** 38 ### Category Stats (Jul 2026) - **Average Rating**: 4.4/5 The average rating of products in this category, based on all submitted ratings *Last updated: July 14, 2026* ## How Does G2 Rank Electronic Trial Master File (eTMF) Software Products? **Why You Can Trust G2's Software Rankings:** - 30 Analysts and Data Experts - 2,300+ Authentic Reviews - 38+ Products - Unbiased Rankings G2's software rankings are built on verified user reviews, rigorous moderation, and a consistent research methodology maintained by a team of analysts and data experts. Each product is measured using the same transparent criteria, with no paid placement or vendor influence. While reviews reflect real user experiences, which can be subjective, they offer valuable insight into how software performs in the hands of professionals. Together, these inputs power the G2 Score, a standardized way to compare tools within every category. ## What Are the Top-Rated Electronic Trial Master File (eTMF) Software Products in 2026? ### 1. [Egnyte](https://www.g2.com/products/egnyte/reviews) Egnyte combines the power of cloud content management, data security, and AI into one intelligent content platform. More than 22,000 customers trust Egnyte to improve employee productivity, automate business processes, and safeguard critical data, in addition to offering specialized content intelligence and automation solutions across industries, including architecture, engineering, and construction (AEC), life sciences, and financial services. **Average Rating:** 4.4/5.0 **Total Reviews:** 1,138 **How Do G2 Users Rate Egnyte?** - **Ease of Use:** 9.0/10 (Category avg: 8.9/10) - **Quality of Support:** 8.8/10 (Category avg: 8.3/10) **Who Is the Company Behind Egnyte?** - **Seller:** [Egnyte](https://www.g2.com/sellers/egnyte) - **Company Website:** https://www.egnyte.com - **Year Founded:** 2008 - **HQ Location:** Mountain View, CA - **Twitter:** @Egnyte (16,127 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/1015589/ (1,302 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** Project Manager, Owner - **Top Industries:** Construction, Marketing and Advertising - **Company Size:** 44% Small-Business, 38% Mid-Market #### What Are Egnyte's Pros and Cons? **Pros:** - Ease of Use (120 reviews) - File Sharing (70 reviews) - Easy Sharing (53 reviews) - Security (46 reviews) - Easy Access (45 reviews) **Cons:** - Expensive (21 reviews) - File Management (18 reviews) - Limited Features (13 reviews) - User Difficulty (13 reviews) - Lacking Features (12 reviews) ### What Do G2 Reviewers Say About Egnyte? *AI-generated summary from verified user reviews* **Pros:** - Users appreciate the **ease of use** of Egnyte, highlighting its user-friendly interface and seamless integration with tools. - Users value the **ease of file sharing** with Egnyte, enabling smooth collaboration and secure access across teams. - Users value the **easy sharing** feature of Egnyte, enhancing collaboration for remote and in-office team members alike. - Users value the **robust security features** of Egnyte, ensuring their data is well protected and compliant. - Users appreciate the **easy access** to documents, enabling seamless sharing and collaboration with peers and subcontractors. **Cons:** - Users find Egnyte to be **expensive** , especially for small businesses, coupled with inflexible billing practices. - Users note the **slow drive accessibility** at startup and challenges with file locks and O365 sharing in Egnyte. - Users find Egnyte's **limited features** frustrating, particularly in bulk actions and user permission customizations. - Users find Egnyte's interface **clunky and slow** , making navigation and file management more challenging than expected. - Users find **lacking features** in Egnyte, struggling with bulk actions and unclear AI training tools. #### What Are Recent G2 Reviews of Egnyte? **"[Secure, Powerful AI Collaboration with Outstanding Workflow Management](https://www.g2.com/survey_responses/egnyte-review-12819916)"** **Rating:** 4.5/5.0 stars *— Konjengbam M.* [Read full review](https://www.g2.com/survey_responses/egnyte-review-12819916) --- **"[Secure, Seamless File Sharing with Strong Collaboration and Governance](https://www.g2.com/survey_responses/egnyte-review-13088921)"** **Rating:** 4.5/5.0 stars *— Dharamveer p.* [Read full review](https://www.g2.com/survey_responses/egnyte-review-13088921) --- #### What Are G2 Users Discussing About Egnyte? - [What is Egnyte used for?](https://www.g2.com/discussions/egnyte-what-is-egnyte-used-for) - 1 comment - [Is egnyte secure?](https://www.g2.com/discussions/is-egnyte-secure) - 1 comment - [What is egnyte used for?](https://www.g2.com/discussions/what-is-egnyte-used-for) - 2 comments - [What is egnyte software?](https://www.g2.com/discussions/what-is-egnyte-software) - 1 comment ### 2. [Viedoc](https://www.g2.com/products/viedoc/reviews) Viedoc streamlines clinical trials with a powerful, web-based eClinical suite centered around EDC. Designed for efficiency, compliance, and seamless collaboration, our feature-rich platform accelerates research and simplifies data collection, management, and analysis. Trusted in 75+ countries, Viedoc powers 7,000+ studies with more than 1.6M+ participants, bringing life-changing treatments to market faster. **Average Rating:** 4.5/5.0 **Total Reviews:** 225 **How Do G2 Users Rate Viedoc?** - **Ease of Use:** 9.2/10 (Category avg: 8.9/10) - **Quality of Support:** 9.2/10 (Category avg: 8.3/10) **Who Is the Company Behind Viedoc?** - **Seller:** [Viedoc Technologies](https://www.g2.com/sellers/viedoc-technologies) - **Company Website:** https://www.viedoc.com/ - **Year Founded:** 2003 - **HQ Location:** Uppsala, Uppsala County - **Twitter:** @ViedocOfficial (200 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/viedoctechnologies/ (129 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** Data Manager, Associate Analyst - **Top Industries:** Pharmaceuticals, Research - **Company Size:** 37% Enterprise, 33% Mid-Market #### What Are Viedoc's Pros and Cons? **Pros:** - Ease of Use (38 reviews) - User Interface (31 reviews) - Intuitive (23 reviews) - Customer Support (22 reviews) - Design Ease (21 reviews) **Cons:** - Slow Performance (13 reviews) - Difficulty (11 reviews) - Access Control (8 reviews) - Form Design Issues (8 reviews) - Missing Features (7 reviews) ### What Do G2 Reviewers Say About Viedoc? *AI-generated summary from verified user reviews* **Pros:** - Users appreciate the **ease of use** in Viedoc, enabling quick setup and automation of repetitive tasks. - Users appreciate the **user-friendly interface** of Viedoc, noting its intuitive design and easy navigation. - Users value the **intuitive design** of Viedoc, enabling quick setup and efficient navigation for complex study structures. - Viedoc's **customer support** is exceptional, offering responsive assistance and valuable resources for smooth user experience. - Users value the **user-friendly design** of Viedoc, simplifying clinical data management and enhancing overall workflow efficiency. **Cons:** - Users experience **slow performance** with Viedoc, particularly when processing large datasets or opening new windows. - Users find the **configuration settings difficult to navigate** and report slow performance with the report models. - Users feel that **role-based access control** in Viedoc can be limiting, affecting collaboration and workflow efficiency. - Users find Viedoc's **form design issues** restrictive and experience challenges with outdated UI and error management. - Users face **missing features** in Viedoc, complicating form creation and integration with other platforms. #### What Are Recent G2 Reviews of Viedoc? **"[Simple, Versatile Design and a Product That Keeps Up With a Fast-Moving Market](https://www.g2.com/survey_responses/viedoc-review-12611501)"** **Rating:** 4.5/5.0 stars *— Marina A.* [Read full review](https://www.g2.com/survey_responses/viedoc-review-12611501) --- **"[Driving Efficiency and Data Quality in Clinical Trial Management](https://www.g2.com/survey_responses/viedoc-review-8698783)"** **Rating:** 5.0/5.0 stars *— DEEKSHITHA V.* [Read full review](https://www.g2.com/survey_responses/viedoc-review-8698783) --- #### What Are G2 Users Discussing About Viedoc? - [What is Viedoc used for?](https://www.g2.com/discussions/what-is-viedoc-used-for) - 1 comment ### 3. [Clinical Research Suite](https://www.g2.com/products/clinical-research-suite/reviews) ABOUT ResearchManager is an all-in-one platform that makes clinical research smarter, faster, and more efficient. With the Clinical Research Suite, we provide a fully integrated solution for academic institutions, healthcare organizations, CROs, and sponsors across the entire clinical research lifecycle. From study setup and regulatory approval to recruitment, data capture, and monitoring. By centralizing processes and data on a single platform, ResearchManager reduces complexity, minimizes errors, and enhances compliance and collaboration. OUR MISSION Our mission is to digitalize, accelerate, and optimize research worldwide, enabling innovative treatments and scientific insights to reach patients sooner. We believe advancing healthcare starts with advancing research, and we empower organizations to make that happen. OUR PLATFORM - THE CLINICAL RESEARCH SUITE Clinical Data Management: Tools to recruit the right participants and efficiently capture, manage, and validate research data, reducing errors and saving time. • Electronic Data Capture (EDC) • Electronic Patient-Reported Outcomes (ePRO) • Randomization and Trial Supply Management (RTSM) • Electronic Informed Consent (eConsent) • Patient Recruitment Clinical Operations: Tools that centralize submissions, documentation, and workflows to streamline trial management and strengthen collaboration. These are all modular and fully configurable. • Clinical Trial Management System (CTMS) • Electronic Trial Master File (eTMF) • Regulatory Information Management System (RIMS) LEARN MORE • Request a FREE Demo:https://my researchmanager.com/en/request-inquiry/ • Get a Price Estimate in 1 Minute: https://my-researchmanager.com/en/pricing/ **Average Rating:** 3.8/5.0 **Total Reviews:** 204 **How Do G2 Users Rate Clinical Research Suite?** - **Ease of Use:** 7.5/10 (Category avg: 8.9/10) - **Quality of Support:** 7.6/10 (Category avg: 8.3/10) **Who Is the Company Behind Clinical Research Suite?** - **Seller:** [ResearchManager](https://www.g2.com/sellers/researchmanager) - **Year Founded:** 2013 - **HQ Location:** Deventer, Overijssel - **Twitter:** @RESEARCH_MGR (96 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/research-manager/ (20 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** PhD student, Researcher - **Top Industries:** Hospital & Health Care, Research - **Company Size:** 55% Enterprise, 33% Small-Business #### What Are Clinical Research Suite's Pros and Cons? **Pros:** - Ease of Use (79 reviews) - Interface Clarity (18 reviews) - User Interface (18 reviews) - Features (17 reviews) - Data Management (14 reviews) **Cons:** - Poor Navigation (24 reviews) - Missing Features (15 reviews) - Difficulty (14 reviews) - Slow Performance (10 reviews) - Data Management Issues (8 reviews) ### What Do G2 Reviewers Say About Clinical Research Suite? *AI-generated summary from verified user reviews* **Pros:** - Users appreciate the **user-friendly interface** of Clinical Research Suite, enhancing their experience with clear structure and organization. - Users appreciate the **interface clarity** of Clinical Research Suite, highlighting its clear organization and ease of use. - Users value the **user-friendly interface** that enhances navigation and organization, streamlining research processes effectively. - Users appreciate the **easy-to-navigate features** of Clinical Research Suite, enhancing their overall experience and efficiency. - Users appreciate the **efficient data management** in Clinical Research Suite, ensuring secure and organized study uploads. **Cons:** - Users find the **poor navigation** of the Clinical Research Suite frustrating and time-consuming, complicating their overall experience. - Users find the **missing features** like customization and detailed guides hinder the overall experience of Clinical Research Suite. - Users face a **steep learning curve** with the Clinical Research Suite, complicating initial navigation and understanding of requirements. - Users find the **slow performance** of the Clinical Research Suite frustrating, particularly when managing large datasets. - Users struggle with **data management issues** as document uploads lead to disorganization and loss of oversight. #### What Are Recent G2 Reviews of Clinical Research Suite? **"[Very friendly user interface](https://www.g2.com/survey_responses/clinical-research-suite-review-11695059)"** **Rating:** 4.5/5.0 stars *— Verified User in Medical Practice* [Read full review](https://www.g2.com/survey_responses/clinical-research-suite-review-11695059) --- **"[Very flexible software](https://www.g2.com/survey_responses/clinical-research-suite-review-10816362)"** **Rating:** 5.0/5.0 stars *— Quinty v.* [Read full review](https://www.g2.com/survey_responses/clinical-research-suite-review-10816362) --- ### 4. [MasterControl Quality Management System](https://www.g2.com/products/mastercontrol-quality-management-system/reviews) MasterControl Quality Excellence is the #1 Quality Management System (QMS) in life sciences. Built on an AI-driven platform, it enables life-sciences companies to enable flexible quality event management, simplified document management, and automated training management—that all work seamlessly together to close the loop on quality. Targeted primarily at quality professionals within the life sciences industry, MasterControl Qx serves a diverse range of organizations, from pharmaceuticals to biotechnology and medical devices. These industries often face stringent regulatory requirements and complex quality assurance processes. MasterControl Qx offers a centralized platform that integrates various quality management functions, allowing users to manage quality events, documentation, training, and audits seamlessly. This integration not only enhances operational efficiency but also ensures that organizations remain compliant with industry standards. One of the standout features of MasterControl Qx is its intelligent automation capabilities. By automating routine quality management tasks, organizations can reduce manual errors and free up valuable time for quality professionals to focus on more strategic initiatives. Additionally, the platform provides robust data insights that empower users to make informed decisions based on real-time information. This data-driven approach enhances the ability to identify trends, monitor compliance, and drive continuous improvement within quality processes. Furthermore, MasterControl Qx is designed to foster collaboration across departments and teams. The platform's connected nature allows for easy sharing of information and documentation, ensuring that all stakeholders are aligned and informed. This collaborative environment not only enhances communication but also supports a culture of quality throughout the organization. By utilizing MasterControl Qx, companies can create a more agile and responsive quality management system that adapts to changing regulatory landscapes and market demands. Overall, MasterControl Quality Excellence (Qx) stands out in the QMS category by providing a holistic solution tailored to the specific needs of the life sciences industry. Its combination of intelligent automation, robust data insights, and collaborative features positions it as a valuable tool for organizations striving to maintain high-quality standards while navigating the complexities of regulatory compliance. **Average Rating:** 4.3/5.0 **Total Reviews:** 522 **How Do G2 Users Rate MasterControl Quality Management System?** - **Ease of Use:** 7.8/10 (Category avg: 8.9/10) - **Quality of Support:** 8.6/10 (Category avg: 8.3/10) **Who Is the Company Behind MasterControl Quality Management System?** - **Seller:** [MasterControl](https://www.g2.com/sellers/mastercontrol) - **Company Website:** https://www.mastercontrol.com?utm_source=linkedin&utm_medium=about&utm_campaign=l1nk3din-sm - **Year Founded:** 1993 - **HQ Location:** Salt Lake City, UT - **Twitter:** @MCMasterControl (6,258 Twitter followers) - **LinkedIn® Page:** https://www.linkedin.com/company/23070/ (742 employees on LinkedIn®) **Who Uses This Product?** - **Who Uses This:** Quality Assurance Specialist, Quality Engineer - **Top Industries:** Pharmaceuticals, Medical Devices - **Company Size:** 65% Mid-Market, 25% Enterprise #### What Are MasterControl Quality Management System's Pros and Cons? **Pros:** - Ease of Use (115 reviews) - Document Management (87 reviews) - Training (65 reviews) - Document Control (47 reviews) - Features (44 reviews) **Cons:** - Not Intuitive (43 reviews) - Learning Curve (42 reviews) - Difficult Usability (32 reviews) - Not User-Friendly (29 reviews) - Complex Setup (27 reviews) ### What Do G2 Reviewers Say About MasterControl Quality Management System? *AI-generated summary from verified user reviews* **Pros:** - Users appreciate the **ease of use** of MasterControl, benefiting from its intuitive interface and customizable features. - Users value the **centralized document management** features of MasterControl, enhancing integration and user experience effectively. - Users value the **user-friendly training integration** and centralized system for managing compliance and quality events effectively. - Users value the **efficient document control** in MasterControl, appreciating easy access to documents and timely upgrades. - Users appreciate the **customizable and user-friendly features** of MasterControl, facilitating efficient quality management processes. **Cons:** - Users find the **interface not intuitive** , struggling with complex setups and unclear iconography affecting user experience. - Users face a **steep learning curve** with MasterControl, particularly during initial setup and navigation between modules. - Users find the **difficult usability** of MasterControl's system a challenge, particularly with report creation and workflow setup. - Users struggle with the **not user-friendly interface** of MasterControl, finding navigation and search features cumbersome and challenging. - Users find the **complex setup** challenging, requiring extensive training to effectively use MasterControl's capabilities. #### What Are Recent G2 Reviews of MasterControl Quality Management System? **"[Integrated, Compliant QMS That Streamlines Regulated Workflows](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-12851642)"** **Rating:** 5.0/5.0 stars *— Yoohan L.* [Read full review](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-12851642) --- **"[A wonderful tool for Life Sciences in an organization!](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-8510804)"** **Rating:** 5.0/5.0 stars *— Liz K.* [Read full review](https://www.g2.com/survey_responses/mastercontrol-quality-management-system-review-8510804) --- #### What Are G2 Users Discussing About MasterControl Quality Management System? - [What is MasterControl Quality Management System used for?](https://www.g2.com/discussions/what-is-mastercontrol-quality-management-system-used-for) - 1 comment - [What is MasterControl Customer Complaints used for?](https://www.g2.com/discussions/what-is-mastercontrol-customer-complaints-used-for) ## What Is Electronic Trial Master File (eTMF) Software? [Clinical Research Software](https://www.g2.com/categories/clinical-research)