We were shown Veeam right from the moment we fully virtualised with VMWare. We already had a backup to disk / image based solution with Physical machines, but that didn't support virtualised environments. I love how simple Veeam was to start using, and it's never caused me a problem with lost recovery points or corruption - touch wood. And that's something I've had in the past from other solutions. Instant VM Recovery is also amazing, I love how you can spin up a full VM from a backup point
I only have 2 real dislikes - number 1, performance with NAS boxes has always been a bottleneck. With physical machines backing up to the same NAS, we could get initial full backups done quicker. Number 2 - excluding certain folders from the backup is either very tricky, or not possible. As it seemingly backs up the Vdisks, I don't believe I can restrict backups from specific folders, at least if I can, I've not seen how.
Make sure you spec up your repository (backup hardware/appliance) correctly to ensure you get the desired throughput with full backups and instant VM restores. If you are backing up 2012R2 VM's and use deduplication, be aware your incremental backups will grow once dedup schedules start changing the disk blocks.
We are using VEEAM for both traditional daily backups, incrementals and fulls, with different schedules to suit the workload, and backup copies, both to secondary storage and cloud backups. This satisfies all our requirements in terms of backup strategy, and simplifies DR.