Bioconductor is a open-source software project that specializes in providing tools for the analysis and comprehension of high-throughput genomic data. Originated in 2001, Bioconductor is built on the R programming language, offering a wide array of statistical and graphical methods designed specifically for bioinformatics applications, including the analysis of DNA microarray, next-generation sequencing, proteomics, and other forms of biological data.Hosted at https://www.bioconductor.org/, the project features a robust repository of R packages that enhance the capabilities of R for genomic data analysis, facilitating cutting-edge bioinformatics research, and supporting reproducible scientific discovery. Bioconductor not only provides tools for the analysis of complex genomic data but also promotes the integration of biological metadata in a seamless and interoperable environment.The community behind Bioconductor includes researchers, developers, and practitioners worldwide, contributing to a vast library of packages aimed at enabling the analysis of large sets of biological information. The platform offers resources for learning and using Bioconductor software, including comprehensive documentation, tutorials, and active user support forums. Bioconductor is ideal for biologists, bioinformaticians, and statisticians looking to apply advanced statistical analysis to genomic data.