Prefect is all about taking the idea of having scheduled Python scripts and easily and expertly tacking on all the things that make an engineer's life easier: UI-based scheduling, parameterization, flow visualization, detailed logging, exception handling, notifications, webhooks, containerization and easy deployments, concurrency. It's like a pure (and massive) value-add system with almost no need to make concessions in how you like to connect to data, transform data, or deliver data. As such I think it's especially powerful when you have a lot of non-standard ETL pipelines going in all directions (i.e. a mountain of tech debt) and you want to clean things up without being forced into restrictive design decisions.
Prefect is really flexible, not just in terms of how you deploy the execution agents, but also in terms of how you want to structure your code and what Prefect features you want to use heavily or lightly. There's no limitation on data sources or integrations: it just fits into whatever you're already doing with Python. It doesn't force you into any mold beyond just using Python, although the concepts of tasks, and the way Prefect handles concurrency, is super helpful if you want to make use of these things. It makes it easy to containerize Python scripts and make every aspect of a data flow deployment modular and flexible. And once you have your settings the way you like them, deploying changes or new flows is easy.
We run about 200 scheduled Prefect flows a day, sending and receiving data between over 50 different systems at our university. Prefect has been a lifesaver. Documentation, support, and the Prefect Slack space have all been super helpful.